Phage Based Diagnostics

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    • Rapid detection of mycobacterial disease
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Menu
  • Home
  • About
    • About PBD Biotech
    • Industry Awards
    • Management Team
    • International
  • Actiphage
    • About Actiphage
    • Benefits of Actiphage
    • Rapid detection of mycobacterial disease
  • Bovine
    • Bovine TB
    • Johne’s Disease
    • Dairy Industry
  • Latest
    • Articles
    • Events
  • Case Studies
  • Research
  • Contact
    • Product Order Form
    • Contacting us

Bovine TB

Actiphage detects the presence of live M. bovis, the bacteria that causes Bovine Tuberculosis, in a sample of blood or milk.

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Johne's Disease testing service

Heartbreak and hope – the story of a new diagnostic for bovine TB

Former dairy farmer Jonnie Yewdall joined vets, farmers and others to discuss a new hope of ending the bTB heartache...

By identifying carriers of the disease at a very early stages of infection, Actiphage enables disease management through the removal of these animals from the herd or prior to movement. 

It also supports the introduction of a vaccine which would provide the ultimate protection for herds.

Current test of bTB lacks sensitivity

The primary screening test for tuberculosis in cattle is the Single Intradermal Comparative Tuberculin Test (SICTT) – a tuberculin skin test that detects the presence of a mycobacterial immune response in the animal.

For this test, a veterinarian injects a small amount of Avian and Bovine tuberculin into a fold of skin to see if there is an immunologic reaction. If the animal is infected a localised swelling can be detected three days later.

The test is thought to be only 50-60% effective, takes three days to produce a result, requires at least two visits by a vet and cannot distinguish between infected and vaccinated cattle, thus removing vaccination as a potential control mechanism.

Clinical tests are defined by two measures, specificity and sensitivity. The UK Government estimates the accuracy of the SICTT skin test to be:

  • Specificity 99.98% – the ability of the test to correctly reject healthy animals that don’t have bovine tuberculosis. 
  • Sensitivity 50 -90% – the ability of the test to correctly identify animals that are infected with the disease. 

Therefore, for a herd with a hundred cows infected with bTB, the SICCT test could miss up to 50, leaving behind a reservoir of infection.Another issue is that SICCT measures the immune response of the animal, rather than detecting the presence of the mycobacteria and actual infection. Therefore, the skin test may miss cattle that are in the early stages of infection and have not yet developed a strong immune response to it, and also give a false positive to animals that have been vaccinated.

Greater sensitivity with Actiphage

A survey using Actiphage of 41 SICTT-positive UK cattle tested at slaughter found live M.bovis in the blood of all animals with visible lesions (13/13) and in 93% (26/28) of animals with no visible lesions (NVL) following post-mortem examination.

This study confirms that relative to SICCT, Actiphage has a sensitivity of 95% and a specificity of 100%.

OIE validation

Further laboratory verification work is being undertaken to prepare for validation to World Organisation for Animal Health (OIE) guidelines.

Suspending service

PBD Biotech has announced that is focusing its efforts on developing Actiphage as a rapid blood test for Human Tuberculosis (TB) and will be suspending its commercial Johne’s Testing Service (from January 2023) More information. Please contact us if you would like to discuss this further.

 

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Which is the best test for bovine TB?

October 14, 2021
The current ‘test and cull’ approach to control of bovine TB does not provide farmers and their vets with effective tools to help prevent and manage the disease

Which is the best test for bovine TB?

October 14, 2021
The current ‘test and cull’ approach to control of bovine TB does not provide farmers and their vets with effective...
Johne's Disease testing service

Heartbreak and hope – the story of a new diagnostic for bovine TB

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developers of phage-based diagnostics

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