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At PBD, we partner to develop Actiphage for the acceleration of latent tuberculosis (LTBI) test and treat campaigns and TB drug research through the following: Laboratory-developed tests to support research studies for latent tuberculosis  screening. Companion diagnostic TB drug research...

Key Actiphage workflow steps Actiphage blood collection 2ml blood sample (sodium heparin) is required. Not refrigerated or frozen; shipped at ambient = 10-24C. Processed to the start of phage incubation, within 48 hours of collection, to prevent white blood cell...

Actiphage detects mycobacterium tuberculosis in latent TB patients associated with progression to active tuberculosis Actiphage provided the first concordant evidence in humans to detect incipient TB in early infection. Actiphage had high correlation of 73% for positive test results in...

Preventive TB treatment Progression from untreated LTBI to TB disease accounts for approximately 80% of TB cases. Testing and treating people living with TB infection is essential to eliminating TB disease. Preventive TB treatment substantially reduces the risk that LTBI...

Role in TB preventive drug development Actiphage is a detection technology that has been shown to  identify patients at greatest risk of progression to TB disease. Actiphage could potentially be used for a “rule-in” preventive therapy diagnostic test where a...

Actiphage is a novel bacteriophage-based assay that infects and lyses active Mtb to release bacterial DNA for PCR based detection. In clinical studies Actiphage has been shown to have: higher specificity and sensitivity than current tests for Latent TB Infection...

On average, 5–10% of people who are infected with TB will develop disease over the course of their lives. Early diagnosis of TB, systematic screening, preventive treatment of persons, and vaccination against TB are some of the key components in...

Find out more about diagnosing TB in humans

Find out more about diagnosing TB in humans

Find out more about diagnosing TB in humans

Actiphage provides a highly specific and sensitive assay for the cost-effective detection of mycobacterial disease in blood.

Actiphage offers benefits over tests that rely on an immune response.