Phage Based Diagnostics

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    • About Actiphage
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    • Rapid detection of mycobacterial disease
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    • Bovine TB
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Benefits of Actiphage

The ability to detect viable MAP or bTB in the blood at an early stage of infection offers greater sensitivity in diagnosis, improved identification of carriers and more effective disease control.

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Actiphage increases the speed and effectiveness of testing..

Faster testing time
Actiphage only requires one visit to collect blood samples and analysis takes 6-8 hours to produce a result.

No ‘cool off’ period
There is no time limit between tests, enabling a continuous programme of testing to be carried out where infection has been detected or is suspected.

Highly sensitive
The test only works on viable mycobacteria. Actiphage is more sensitive than any other test currently available, able to detect fewer than 10 live mycobacteria in a 2ml blood sample.

Highly specific
The technology has in-built high-level specificity controls and is able to identify any species of mycobacteria that is susceptible to the bacteriophage, including MAP (Johne’s disease) and M.bovis (bovine TB).

High accuracy
Actiphage can reproducibly distinguish between live and dead mycobacteria, meaning that a positive result will only be delivered if there are live mycobacteria in the sample.

As a DIVA tool (Differentiating Vaccinated from Infected Animals):
Uniquely, Actiphage directly detects live mycobacteria so will always produce a negative result when used on vaccinated animals even if they might have a positive skin test result. This opens up the possibility of, for example, the roll-out of vaccination programmes for bovine TB.

Testing services

To find out more about our MAP/Johne's Disease testing service contact us.

Towards eradicating tuberculosis

A regime of testing and removal supported by good hygiene has been shown to reduce the reservoir of disease on-farm.

This is a vital first step towards eradication of these devastating diseases.

Related content

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bison MAP diagnostic

Actiphage identifies strain of mycobacteria in blood of bison

May 26, 2022
Results presented at ICP (12-16th June) from first study in North American bison, shows capacity of Actiphage to sub-type mycobacteria in blood.
bison MAP diagnostic

Actiphage identifies strain of mycobacteria in blood of bison

May 26, 2022
Results presented at ICP (12-16th June) from first study in North American bison, shows capacity of Actiphage to sub-type mycobacteria...
ECCMID

Actiphage® TB diagnostic finds live mycobacterium tuberculosis in the blood of people with incipient TB

April 23, 2022
A clinical trial of Actiphage, a promising new diagnostic for tuberculosis infection, has shown for the first time that live bacteria can be detected in the blood of people with incipient TB infection.
ECCMID

Actiphage® TB diagnostic finds live mycobacterium tuberculosis in the blood of people with incipient TB

April 23, 2022
A clinical trial of Actiphage, a promising new diagnostic for tuberculosis infection, has shown for the first time that live...
ECCMID conference

23-26 April 2022

Novel TB diagnostics paper to be presented at ECCMID 2022

April 4, 2022
Jee-Whang Kim of Leicester Tuberculosis Research Group (LTBRG) is to present a paper in the ‘hot topics in tuberculosis’ session at ECCMID 2022
ECCMID conference

23-26 April 2022

Novel TB diagnostics paper to be presented at ECCMID 2022

April 4, 2022
Jee-Whang Kim of Leicester Tuberculosis Research Group (LTBRG) is to present a paper in the ‘hot topics in tuberculosis’ session...

From Farm to Fork, the power of phage

February 24, 2022
Phage diagnostics have potential for cost-effective detection of bacterial infections across medical, food, and agricultural industries says new review.

From Farm to Fork, the power of phage

February 24, 2022
Phage diagnostics have potential for cost-effective detection of bacterial infections across medical, food, and agricultural industries says new review.
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developers of phage-based diagnostics

Contact Us

PBD Biotech Ltd
Link House, Elm Farm Park,
Great Green, Thurston,
Suffolk IP31 3SH,
United Kingdom

Registered Company Address
Ingenuity Centre,
University of Nottingham,
Innovation Park, Triumph Rd,
Nottingham NG7 2TU,
United Kingdom

T: 01359 231856
info@pbdbio.com

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If you are going @CheshireShow there is an opportunity to talk to @ZaraBewizibet senior scientific adviser to Defra TB Policy. She is on the Cheshire Badger Vaccination Project @CBVP2021 stand. Good to see some joined up thinking #BadgerTrust #EndTB

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